"Isn't that interesting, Senator Casey, that Barack Obama, your candidate, can walk before 15000 people with complete calm and assurance, but he seems a little out of place in A) a bowling alley and B) a diner. What is the problem with your guy?"(see video at 1:35)
In a perfect world, Senator Casey's response to Chris Matthews' question would be something along the lines of "No, Chris, it isn't interesting. It isn't even noteworthy, much less relevant. And you are an embarrassment."
Or maybe just a long yawn and some blinking would have been more appropriate. I guess that'd just be too elitist.